Linkage between the loci for benign (Becker-type) X-borne muscular dystrophy and deutan colour blindness.
نویسندگان
چکیده
et. al, 1968/1969) and give an estimate of 0-23 for the recombination fraction with 9500 confidence limits of 0-13 to 0 43. These results confirm the linkage relationships between deutan colour blindness and Becker muscular dystrophy but since the loci for Duchenne muscular dystrophy and colour blindness are not within measurable distance of each other these results indicate that the Becker and Duchenne types of X-linked muscular dystrophy are not allelic.
منابع مشابه
X mapping in man: evidence against direct measurable linkage between ocular albinism and deutan colour blindness.
A Newfoundland kindred in which ocular albinism and deutan colour blindness are segregating provides strong evidence against the loci for these two X-borne characters being within direct measurable distance of each other.
متن کاملGenetic linkage between the loci for colour blindness and Duchenne type muscular dystrophy.
Duchenne type muscular dystrophy is a condition which begins in infancy or early childhood, and is characterized by progressive muscle weakness leading to death in the late teens or early twenties (Walton and Nattrass, I954). This type of muscular dystrophy has been variously referred to as 'pseudohypertrophic muscular dystrophy' (Bell, I948), 'progressive muscular dystrophy of childhood' (Step...
متن کاملLinkage analysis of a DNA polymorphism proximal to the Duchenne and Becker muscular dystrophy loci on the short arm of the X chromosome.
The inheritance of a restriction fragment length polymorphism (RFLP) detected by a cloned DNA sequence (p754) from the short arm of the X chromosome has been studied in 14 Duchenne muscular dystrophy kindreds and six Becker muscular dystrophy kindreds. The linkage data obtained suggest that both the DMD and BMD loci are located in the same region (p21) on the short arm of the X chromosome at a ...
متن کاملLinkage studies in Duchenne and Becker muscular dystrophies.
We have studied the inheritance of four cloned DNA sequences which recognise restriction fragment length polymorphisms on the short arm of the X chromosome in families with Becker and Duchenne muscular dystrophy. We have confirmed linkage of two probe loci to the disease loci and have combined our results with those previously published to give a maximum lod score of 11.642 at a recombination f...
متن کاملThe Diagnostic Value of Utrophin in Mild Dystrophinopathy (Becker Muscular Dystrophy)
Background and Objective: Becker Muscular Dystrophy (BMD) is a subtype of dystrophinopathies and designated as “mild form of dystrophinopathy”. The frequency rate of the disease is 1:18000 to 1:30000 in different populations and the symptoms are presented at about 8-9 years of age. The diagnostic panel composed of Serum Ceratin Kinase (SCK) measurement, Electromyography (EMG), and as a major...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 11 4 شماره
صفحات -
تاریخ انتشار 1974